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Quantitative evaluation of retinal degeneration in royal college of surgeons rats by contrast enhanced ultrahigh resolution optical coherence tomography
Author(s): Jia-Pu Syu; Min-Jyun Su; Po-Wei Chen; Chang-Chih Ke; Shih-Hwa Chiou; Wen-Chuan Kuo
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Paper Abstract

This study presents a spectral domain optical coherence tomography (SD-OCT) using supercontinuum laser combined with a fundus photography for in vivo high-resolution imaging of retinal degeneration in Royal College of Surgeons (RCS-/- rat). These findings were compared with the Sprague-Dawley (SD) rats and the corresponding histology. Quantitative measurements show that changes in thickness were not significantly different between SD control and young RCS retinas (4 weeks). However, in old RCS rats (55 weeks), the thickness of photoreceptor layer decreased significantly as compared to young RCS rats (both 4 weeks and 5 weeks). After contrast enhancement method, this platform will be useful for the quantitative evaluation of the degree of retinal degeneration, treatment outcome after therapy, and drug screening development in the future.

Paper Details

Date Published: 19 February 2018
PDF: 7 pages
Proc. SPIE 10474, Ophthalmic Technologies XXVIII, 104741V (19 February 2018); doi: 10.1117/12.2289610
Show Author Affiliations
Jia-Pu Syu, National Yang-Ming Univ. (Taiwan)
Min-Jyun Su, National Yang-Ming Univ. (Taiwan)
Po-Wei Chen, National Yang-Ming Univ. (Taiwan)
Chang-Chih Ke, National Yang-Ming Univ. (Taiwan)
Shih-Hwa Chiou, National Yang-Ming Univ. (Taiwan)
Wen-Chuan Kuo, National Yang-Ming Univ. (Taiwan)


Published in SPIE Proceedings Vol. 10474:
Ophthalmic Technologies XXVIII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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