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Cell division is coupled to the optical redox ratio (Conference Presentation)
Author(s): Rupsa Datta; Zhaoqi Li; Allison Lau; Matthew Vander Heiden; Melissa C. Skala
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Paper Abstract

The cell cycle is extensively characterized, yet there is much to learn about the decision-making process involved in cell division. Here, the optical redox ratio (ratio of NADH to FAD fluorescence intensity) of MCF10A cells was imaged every 20 minutes over 12 hours using multiphoton microscopy. Cell tracking was used to monitor individual cells over time. We found a positive correlation in the variations of the optical redox ratio with the phases of the entire cell cycle. This study reveals the novel role of redox signaling in the progression the cell cycle.

Paper Details

Date Published: 15 March 2018
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Proc. SPIE 10504, Biophysics, Biology and Biophotonics III: the Crossroads, 1050405 (15 March 2018); doi: 10.1117/12.2289514
Show Author Affiliations
Rupsa Datta, Morgridge Institute for Research (United States)
Zhaoqi Li, The David H. Koch Institute for Integrative Cancer Research (United States)
Allison Lau, The David H. Koch Institute for Integrative Cancer Research (United States)
Matthew Vander Heiden, The David H. Koch Institute for Integrative Cancer Research (United States)
Melissa C. Skala, Morgridge Institute for Research (United States)
Univ. of Wisconsin-Madison (United States)


Published in SPIE Proceedings Vol. 10504:
Biophysics, Biology and Biophotonics III: the Crossroads
Adam Wax; Vadim Backman, Editor(s)

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