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Proceedings Paper

Two-dimensional auto-correlation analysis and Fourier-transform analysis of second-harmonic-generation image for quantitative analysis of collagen fiber in human facial skin
Author(s): Yuki Ogura; Yuji Tanaka; Eiji Hase; Toyonobu Yamashita; Takeshi Yasui
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Paper Abstract

We compare two-dimensional auto-correlation (2D-AC) analysis and two-dimensional Fourier transform (2D-FT) for evaluation of age-dependent structural change of facial dermal collagen fibers caused by intrinsic aging and extrinsic photo-aging. The age-dependent structural change of collagen fibers for female subjects’ cheek skin in their 20s, 40s, and 60s were more noticeably reflected in 2D-AC analysis than in 2D-FT analysis. Furthermore, 2D-AC analysis indicated significantly higher correlation with the skin elasticity measured by Cutometer® than 2D-AC analysis. 2D-AC analysis of SHG image has a high potential for quantitative evaluation of not only age-dependent structural change of collagen fibers but also skin elasticity.

Paper Details

Date Published: 23 February 2018
PDF: 7 pages
Proc. SPIE 10498, Multiphoton Microscopy in the Biomedical Sciences XVIII, 104982M (23 February 2018); doi: 10.1117/12.2289226
Show Author Affiliations
Yuki Ogura, Tokushima Univ. (Japan)
Shiseido Co., Ltd. (Japan)
Yuji Tanaka, Osaka Univ. (Japan)
Eiji Hase, Tokushima Univ. (Japan)
Toyonobu Yamashita, Shiseido Co., Ltd. (Japan)
Takeshi Yasui, Tokushima Univ. (Japan)
Osaka Univ. (Japan)


Published in SPIE Proceedings Vol. 10498:
Multiphoton Microscopy in the Biomedical Sciences XVIII
Ammasi Periasamy; Peter T. C. So; Karsten König; Xiaoliang S. Xie, Editor(s)

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