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Proceedings Paper

Label-free counting of circulating cells by in vivo photoacoustic flow cytometry
Author(s): Quanyu Zhou; Ping Yang; Qiyan Wang; Kai Pang; Hui Zhou; Hao He; Xunbin Wei
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Paper Abstract

Melanoma, developing from melanocytes, is the most serious type of skin cancer. Circulating melanoma cells, the prognosis marker for metastasis, are present in the circulation at the early stage. Thus, quantitative detection of rare circulating melanoma cells is essential for monitoring tumor metastasis and prognosis evaluation. Compared with in vitro assays, in vivo flow cytometry is able to identify circulating tumor cells without drawing blood. Here, we built in vivo photoacoustic flow cytometry based on the high absorption coefficient of melanoma cells, which is applied to labelfree counting of circulating melanoma cells in tumor-bearing mice.

Paper Details

Date Published: 19 February 2018
PDF: 6 pages
Proc. SPIE 10495, Biophotonics and Immune Responses XIII, 104950T (19 February 2018); doi: 10.1117/12.2289216
Show Author Affiliations
Quanyu Zhou, Shanghai Jiao Tong Univ. (China)
Ping Yang, Shanghai Jiao Tong Univ. (China)
Qiyan Wang, Shanghai Jiao Tong Univ. (China)
Kai Pang, Shanghai Jiao Tong Univ. (China)
Hui Zhou, Reaching Biotech Co., Ltd. (China)
Hao He, Shanghai Jiao Tong Univ. (China)
Xunbin Wei, Shanghai Jiao Tong Univ. (China)

Published in SPIE Proceedings Vol. 10495:
Biophotonics and Immune Responses XIII
Wei R. Chen, Editor(s)

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