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Proceedings Paper

Wide-field high spatial frequency domain imaging of tissue microstructure
Author(s): Weihao Lin; Bixin Zeng; Zili Cao; Danfeng Zhu; M. Xu
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Paper Abstract

Wide-field tissue imaging is usually not capable of resolving tissue microstructure. We present High Spatial Frequency Domain Imaging (HSFDI) - a noncontact imaging modality that spatially maps the tissue microscopic scattering structures over a large field of view. Based on an analytical reflectance model of sub-diffusive light from forward-peaked highly scattering media, HSFDI quantifies the spatially-resolved parameters of the light scattering phase function from the reflectance of structured light modulated at high spatial frequencies. We have demonstrated with ex vivo cancerous tissue to validate the robustness of HSFDI in significant contrast and differentiation of the microstructutral parameters between different types and disease states of tissue.

Paper Details

Date Published: 12 February 2018
PDF: 6 pages
Proc. SPIE 10484, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI, 1048416 (12 February 2018); doi: 10.1117/12.2289207
Show Author Affiliations
Weihao Lin, Wenzhou Medical Univ. (China)
Bixin Zeng, Wenzhou Medical Univ. (China)
Zili Cao, Wenzhou Medical Univ. (China)
Danfeng Zhu, Wenzhou Medical Univ. (China)
M. Xu, Wenzhou Medical Univ. (China)
Fairfield Univ. (United States)

Published in SPIE Proceedings Vol. 10484:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI
Tuan Vo-Dinh; Anita Mahadevan-Jansen; Warren S. Grundfest M.D., Editor(s)

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