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Proceedings Paper

Lung biopsy assessment with dynamic cell optical imaging (Conference Presentation)
Author(s): Emilie Benoit a la Guillaume; Clement Apelian; Eugénie Dalimier; Claude Boccara; Audrey Mansuet-Lupo; Guillaume Chassagnon; Marie-Pierre Revel
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Paper Abstract

Transthoracic core-needle biopsy under imaging guidance is a common procedure in lung cancer diagnosis. It is performed in order to extract material for histology from a nodule that has previously been detected with radiography or computed tomography in the patient’s chest. In order to avoid recalling for non-diagnostic material, the radiologists are used to performing several biopsies so that the chance of resection of relevant material is increased. The use of a real-time tool for lung biopsy assessment during biopsy procedure would be valuable to decrease the number of biopsies thus decreasing the risk of complications. As an answer to this need, LLTech develops an optical imaging device for real time biopsy assessment at cellular level. Based on full-field optical coherence tomography, the system performs micron resolution optical virtual slices in the sample depth within a few minutes. In addition, benefiting from its high-speed acquisition capability, the system quickly records the evolution of this optical slice over time, thus highlighting intracellular residual movements of freshly excised tissue. Both the tissue architecture and the intracellular activity are imaged and combined in an exhaustive analysis that favors the pathologists reading. LLTech presents the images obtained on dozens of lung biopsies in collaboration with Cochin Hospital radiology and pathology departments to evaluate the potential of dynamic cell imaging on lung cancer assessment.

Paper Details

Date Published: 14 March 2018
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Proc. SPIE 10470, Endoscopic Microscopy XIII, 104700C (14 March 2018); doi: 10.1117/12.2289142
Show Author Affiliations
Emilie Benoit a la Guillaume, LLTech SAS (France)
Clement Apelian, LLTech SAS (France)
Institut Langevin, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (France)
Eugénie Dalimier, LLTech SAS (France)
Claude Boccara, LLTech SAS (France)
Institut Langevin, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (France)
Audrey Mansuet-Lupo, Hopitaux Univ. Paris-Centre, Assistance Publique Hopitaux de Paris (France)
Guillaume Chassagnon, Hôpitaux Univ. Paris Ctr. (France)
Marie-Pierre Revel, Hôpitaux Univ. Paris Ctr. (France)


Published in SPIE Proceedings Vol. 10470:
Endoscopic Microscopy XIII
Guillermo J. Tearney; Thomas D. Wang; Melissa J. Suter, Editor(s)

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