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Hemodynamic monitoring in different cortical layers with a single fiber optical system
Author(s): Linhui Yu; M. Sohail Noor; Zelma H. T. Kiss; Kartikeya Murari
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Paper Abstract

Functional monitoring of highly-localized deep brain structures is of great interest. However, due to light scattering, optical methods have limited depth penetration or can only measure from a large volume. In this research, we demonstrate continuous measurement of hemodynamics in different cortical layers in response to thalamic deep brain stimulation (DBS) using a single fiber optical system. A 200-μm-core-diameter multimode fiber is used to deliver and collect light from tissue. The fiber probe can be stereotaxically implanted into the brain region of interest at any depth to measure the di use reflectance spectra from a tissue volume of 0.02-0.03 mm3 near the fiber tip. Oxygenation is then extracted from the reflectance spectra using an algorithm based on Monte Carlo simulations. Measurements were performed on the surface (cortical layer I) and at 1.5 mm depth (cortical layer VI) of the motor cortex in anesthetized rats with thalamic DBS. Preliminary results revealed the oxygenation changes in response to DBS. Moreover, the baseline as well as the stimulus-evoked change in oxygenation were different at the two depths of cortex.

Paper Details

Date Published: 12 February 2018
PDF: 7 pages
Proc. SPIE 10481, Neural Imaging and Sensing 2018, 104811H (12 February 2018); doi: 10.1117/12.2289138
Show Author Affiliations
Linhui Yu, Univ. of Calgary (Canada)
M. Sohail Noor, Univ. of Calgary (Canada)
Zelma H. T. Kiss, Univ. of Calgary (Canada)
Kartikeya Murari, Univ. of Calgary (Canada)


Published in SPIE Proceedings Vol. 10481:
Neural Imaging and Sensing 2018
Qingming Luo; Jun Ding, Editor(s)

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