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Proceedings Paper

Clinical detection studies of Barrett's metaplasia and oesophageal adenocarcinoma by means of laser-induced fluorescence
Author(s): Annika M.K. Nilsson; Christer Stael von Holstein; Stefan Andersson-Engels; Roger Willen; Bruno Walther; Katarina Svanberg M.D.
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Paper Abstract

Five patients with Barrett's metaplastic epithelium were investigated by means of laser- induced fluorescence after low-dose i.v. injection (0.35 mg/kg b.w.) of PhotofrinR in connection with endoscopy procedures. The excitation wavelength was 405 nm. Recorded fluorescence spectra were evaluated by forming ratios with the photosensitizer fluorescence as numerator and the autofluorescence as denominator. Two patients had no evidence of malignancy and their fluorescence ratios were consequently rather small, whereas the other three patients had adenocarcinoma and showed considerably higher ratios. The results indicate that laser-induced fluorescence can be used as an aid in detecting malignant transformations in Barrett's metaplasia.

Paper Details

Date Published: 27 December 1995
PDF: 8 pages
Proc. SPIE 2627, Optical Biopsies, (27 December 1995); doi: 10.1117/12.228903
Show Author Affiliations
Annika M.K. Nilsson, Lund Institute of Technology (Sweden)
Christer Stael von Holstein, Lund Univ. Hospital (Sweden)
Stefan Andersson-Engels, Lund Institute of Technology (Sweden)
Roger Willen, Lund Univ. Hospital (Sweden)
Bruno Walther, Lund Univ. Hospital (Sweden)
Katarina Svanberg M.D., Lund Univ. Hospital (Sweden)

Published in SPIE Proceedings Vol. 2627:
Optical Biopsies
Rinaldo Cubeddu; Serge R. Mordon; Katarina Svanberg M.D., Editor(s)

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