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Monitoring of tissue heating with medium intensity focused ultrasound via four dimensional optoacoustic tomography
Author(s): Francisco Javier Oyaga Landa; Silvia Ronda Penacoba; Xosé Luís Deán-Ben; Francisco Montero de Espinosa; Daniel Razansky
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Paper Abstract

Medium intensity focused ultrasound (MIFU) holds promise in important clinical applications. Generally, the aim in MIFU is to stimulate physiological mechanisms that reinforce healing responses, avoiding reaching temperatures that can cause permanent tissue damage. The outcome of interventions is then strongly affected by the temperature distribution in the treated region, and accurate monitoring represents a significant clinical need. In this work, we showcase the capacities of 4D optoacoustic imaging to monitor tissue heating during MIFU. The proposed method allows localizing the ultrasound focus, estimating the peak temperature and measuring the size of the heat-affected volume. Calibration experiments in a tissue-mimicking phantom demonstrate that the optoacoustically-estimated temperature accurately matches thermocouple readings. The good performance of the suggested approach in real tissues is further showcased in experiments with bovine muscle samples.

Paper Details

Date Published: 19 February 2018
PDF: 7 pages
Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104945J (19 February 2018); doi: 10.1117/12.2288939
Show Author Affiliations
Francisco Javier Oyaga Landa, Helmholtz Zentrum München GmbH (Germany)
Technische Univ. München (Germany)
Silvia Ronda Penacoba, Instituto de Tecnologías Físicas y de la Información (Spain)
Xosé Luís Deán-Ben, Helmholtz Zentrum München GmbH (Germany)
Francisco Montero de Espinosa, Consejo Superior de Investigaciones Científicas (Spain)
Daniel Razansky, Helmholtz Zentrum München GmbH (Germany)
Technische Univ. München (Germany)

Published in SPIE Proceedings Vol. 10494:
Photons Plus Ultrasound: Imaging and Sensing 2018
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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