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Proceedings Paper

High sensitivity optical molecular imaging system
Author(s): Yu An; Gao Yuan; Chao Huang; Shixin Jiang; Peng Zhang; Kun Wang; Jie Tian
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Paper Abstract

Optical Molecular Imaging (OMI) has the advantages of high sensitivity, low cost and ease of use. By labeling the regions of interest with fluorescent or bioluminescence probes, OMI can noninvasively obtain the distribution of the probes in vivo, which play the key role in cancer research, pharmacokinetics and other biological studies. In preclinical and clinical application, the image depth, resolution and sensitivity are the key factors for researchers to use OMI. In this paper, we report a high sensitivity optical molecular imaging system developed by our group, which can improve the imaging depth in phantom to nearly 5cm, high resolution at 2cm depth, and high image sensitivity. To validate the performance of the system, special designed phantom experiments and weak light detection experiment were implemented. The results shows that cooperated with high performance electron-multiplying charge coupled device (EMCCD) camera, precision design of light path system and high efficient image techniques, our OMI system can simultaneously collect the light-emitted signals generated by fluorescence molecular imaging, bioluminescence imaging, Cherenkov luminance and other optical imaging modality, and observe the internal distribution of light-emitting agents fast and accurately.

Paper Details

Date Published: 13 February 2018
PDF: 6 pages
Proc. SPIE 10487, Multimodal Biomedical Imaging XIII, 104870L (13 February 2018); doi: 10.1117/12.2288908
Show Author Affiliations
Yu An, Institute of Automation (China)
Gao Yuan, Institute of Automation (China)
Chao Huang, Institute of Automation (China)
Shixin Jiang, Beijing Jiaotong Univ. (China)
Peng Zhang, Beijing Jiaotong Univ. (China)
Kun Wang, Institute of Automation (China)
Jie Tian, Institute of Automation (China)

Published in SPIE Proceedings Vol. 10487:
Multimodal Biomedical Imaging XIII
Fred S. Azar; Xavier Intes, Editor(s)

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