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Proceedings Paper

Optical instrumentation suitable for a real-time dosimetry during photodynamic therapy
Author(s): Francois H. Guillemin; Ousama M. A'Amar; Hadjira Rezzoug; Dominique Lignon; F. Jaffry; C. Abdulnour; Laure Muller; Edouard Yvroud; Jean-Louis Merlin; Yves Granjon; Lina Bolotina-Bezdetnaya; Nadia Zeghari; Kamila Khemis; Muriel Barberi-Heyob; Anne Meunier-Reynes; Alexander Ya. Potapenko; Dominique Notter; C. Vigneron
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Paper Abstract

The aim of a dosimetry for the photodynamic therapy (PDT) is to optimize the therapeutic index: destruction of the pathological areas without impairing surrounding healthy tissue. The sensitizer concentration (PS), the global extinction factor (Sigma) eff and the partial pressure of oxygen PO2 in the tumor are the parameters to be studied from the backscattered light during irradiation. A spectrofluorimeter, suitable for flexible endoscopes, has been designed for measurement of (PS) in situ; kinetics of fixation of the sensitizer in the tumor and in healthy tissues allow the user to choose the optimal schedule for treatment; follow-up of the variation of (PS) during irradiation gives an idea of the photochemical reactions. To measure (Sigma) eff in the situation of an interstitial treatment we use the backscattered signal of the excitating light collected through the emitting fiber itself and several contiguous receiving optical fibers. The prototype of this device is 2 mm in diameter. The calculation of the depth of penetration allows computation of light isodoses in the tumor. To have an idea of the available oxygen we measure the absorption of red light by reduced haemoglobin. A general organization chart of the dosimetry shows the various parameters and interactions working towards the therapeutic result.

Paper Details

Date Published: 27 December 1995
PDF: 8 pages
Proc. SPIE 2627, Optical Biopsies, (27 December 1995); doi: 10.1117/12.228879
Show Author Affiliations
Francois H. Guillemin, Ctr. Alexis Vautrin and Ctr. de Recherche en Automatique de Nancy (France)
Ousama M. A'Amar, Ctr. Alexis Vautrin and Ctr. de Recherche en Automatique de Nancy (France)
Hadjira Rezzoug, Ctr. Alexis Vautrin (France)
Dominique Lignon, Ctr. Alexis Vautrin and Ctr. de Recherche en Automatique de Nancy (France)
F. Jaffry, Ctr. Alexis Vautrin and Ctr. de Recherche en Automatique de Nancy (France)
C. Abdulnour, Ctr. de Recherche en Automatique de Nancy (France)
Laure Muller, Ctr. de Recherche en Automatique de Nancy (France)
Edouard Yvroud, Ctr. Alexis Vautrin and Ctr. de Recherche en Automatique de Nancy (France)
Jean-Louis Merlin, Ctr. Alexis Vautrin (France)
Yves Granjon, Ctr. de Recherche en Automatique de Nancy (France)
Lina Bolotina-Bezdetnaya, Ctr. Alexis Vautrin and Russian State Medical Univ. (France)
Nadia Zeghari, Ctr. Alexis Vautrin (France)
Kamila Khemis, Ctr. Alexis Vautrin and Ctr. de Recherche en Automatique de Nancy (France)
Muriel Barberi-Heyob, Ctr. Alexis Vautrin (France)
Anne Meunier-Reynes, Ctr. Alexis Vautrin (France)
Alexander Ya. Potapenko, Russian State Medical Univ. (Russia)
Dominique Notter, Univ. de Nancy I (France)
C. Vigneron, Univ. de Nancy I (France)


Published in SPIE Proceedings Vol. 2627:
Optical Biopsies
Rinaldo Cubeddu; Serge R. Mordon; Katarina Svanberg, Editor(s)

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