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Light propagation analysis in nervous tissue for wireless optogenetic nanonetworks
Author(s): Stefanus Wirdatmadja; Pedram Johari; Sasitharan Balasubramaniam; Yongho Bae; Michal K. Stachowiak; Josep M. Jornet
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Paper Abstract

In recent years, numerous methods have been sought for developing novel solutions to counter neurodegenerative diseases. An objective that is being investigated by researchers is to develop cortical implants that are able to wirelessly stimulate neurons at the single cell level. This is a major development compared to current solutions that use electrodes, which are only able to target a population of neurons, or optogenetics, which requires optical fiber-leads to be embedded deep into the brain. In this direction, the concept of wireless optogenetic nanonetworks has been recently introduced. In such architecture, miniature devices are implanted in the cortex for neuronal stimulation through optogenetics. One of the aspects that will determine the topology and performance of wireless optogenetic nanonetworks is related to light propagation in genetically-engineered neurons. In this paper, a channel model that captures the peculiarities of light propagation in neurons is developed. First, the light propagation behavior using the modified Beer-Lambert law is analyzed based on the photon transport through the nervous tissue. This includes analyzing the scattering light diffraction and diffusive reflection that results from the absorption of neural cell chromophores, as well as validating the results by means of extensive multiphysics simulations. Then, analysis is conducted on the path loss through cells at different layers of the cortex by taking into account the multi-path phenomenon. Results show that there is a light focusing effect in the soma of neurons that can potentially help the to stimulate the target cells.

Paper Details

Date Published: 14 February 2018
PDF: 10 pages
Proc. SPIE 10482, Optogenetics and Optical Manipulation 2018, 104820R (14 February 2018); doi: 10.1117/12.2288786
Show Author Affiliations
Stefanus Wirdatmadja, Tampere Univ. of Technology (Finland)
Pedram Johari, Univ. at Buffalo (United States)
Sasitharan Balasubramaniam, Tampere Univ. of Technology (Finland)
Yongho Bae, Univ. at Buffalo (United States)
Michal K. Stachowiak, Univ. at Buffalo (United States)
Josep M. Jornet, Univ. at Buffalo (United States)

Published in SPIE Proceedings Vol. 10482:
Optogenetics and Optical Manipulation 2018
Samarendra K. Mohanty; Nitish V. Thakor; E. Duco Jansen, Editor(s)

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