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Proceedings Paper

Multimodal autofluorescence detection of cancer: from single cells to living organism
Author(s): J. Horilova; B. Cunderlikova; M. Cagalinec; D. Chorvat; A. Marcek Chorvatova
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Paper Abstract

Multimodal optical imaging of suspected tissues is showing to be a promising method for distinguishing suspected cancerous tissues from healthy ones. In particular, the combination of steady-state spectroscopic methods with timeresolved fluorescence provides more precise insight into native metabolism when focused on tissue autofluorescence. Cancer is linked to specific metabolic remodelation detectable spectroscopically. In this work, we evaluate possibilities and limitations of multimodal optical cancer detection in single cells, collagen-based 3D cell cultures and in living organisms (whole mice), as a representation of gradually increasing complexity of model systems.

Paper Details

Date Published: 23 February 2018
PDF: 10 pages
Proc. SPIE 10498, Multiphoton Microscopy in the Biomedical Sciences XVIII, 104980G (23 February 2018); doi: 10.1117/12.2288785
Show Author Affiliations
J. Horilova, International Laser Ctr. (Slovakia)
Univ. of SS. Cyril and Methodius (Slovakia)
B. Cunderlikova, International Laser Ctr. (Slovakia)
Comenius Univ. (Slovakia)
M. Cagalinec, Univ. of Tartu (Estonia)
Institute of Molecular Physiology and Genetics (Slovakia)
D. Chorvat, International Laser Ctr. (Slovakia)
A. Marcek Chorvatova, International Laser Ctr. (Slovakia)
Univ. of SS. Cyril and Methodius (Slovakia)

Published in SPIE Proceedings Vol. 10498:
Multiphoton Microscopy in the Biomedical Sciences XVIII
Ammasi Periasamy; Peter T. C. So; Karsten König; Xiaoliang S. Xie, Editor(s)

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