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Highly-sensitive and large-dynamic diffuse optical tomography system for breast tumor detection
Author(s): Wenwen Du; Limin Zhang; Guoyan Yin; Yanqi Zhang; Huijuan Zhao; Feng Gao
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Paper Abstract

Diffuse optical tomography (DOT) as a new functional imaging has important clinical applications in many aspects such as benign and malignant breast tumor detection, tumor staging and so on. For quantitative detection of breast tumor, a three-wavelength continuous-wave DOT prototype system combined the ultra-high sensitivity of the photon-counting detection and the measurement parallelism of the lock-in technique was developed to provide high temporal resolution, high sensitivity, large dynamic detection range and signal-to-noise ratio. Additionally, a CT-analogous scanning mode was proposed to cost-effectively increase the detection data. To evaluate the feasibility of the system, a series of assessments were conducted. The results demonstrate that the system can obtain high linearity, stability and negligible inter-wavelength crosstalk. The preliminary phantom experiments show the absorption coefficient is able to be successfully reconstructed, indicating that the system is one of the ideal platforms for optical breast tumor detection.

Paper Details

Date Published: 20 February 2018
PDF: 8 pages
Proc. SPIE 10505, High-Speed Biomedical Imaging and Spectroscopy III: Toward Big Data Instrumentation and Management, 1050515 (20 February 2018); doi: 10.1117/12.2288725
Show Author Affiliations
Wenwen Du, Tianjin Univ. (China)
Limin Zhang, Tianjin Univ. (China)
Guoyan Yin, Tianjin Univ. (China)
Yanqi Zhang, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)


Published in SPIE Proceedings Vol. 10505:
High-Speed Biomedical Imaging and Spectroscopy III: Toward Big Data Instrumentation and Management
Kevin K. Tsia; Keisuke Goda, Editor(s)

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