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Adaptive optics with combined optical coherence tomography and scanning laser ophthalmoscopy for in vivo mouse retina imaging
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Paper Abstract

Optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) are two state-of-the-art imaging technologies commonly used to study retina. Adaptive Optics (AO) methodologies enable high-fidelity correction of ocular aberrations, resulting in improved resolution and sensitivity for both SLO and OCT systems. Here we present work integrating OCT into a previously described mouse retinal AO-SLO system, allowing simultaneous reflectance and fluorescence imaging. The new system allows simultaneous data acquisition of AO-SLO and AO-OCT, facilitating registration and comparison of data from both modalities. The system has data acquisition speed of 200 kHz A-scans/pixel, and high volumetric resolution.

Paper Details

Date Published: 18 March 2018
PDF: 9 pages
Proc. SPIE 10474, Ophthalmic Technologies XXVIII, 1047427 (18 March 2018); doi: 10.1117/12.2288607
Show Author Affiliations
Pengfei Zhang, Univ. of California, Davis (United States)
Daniel J. Wahl, Simon Fraser Univ. (Canada)
Jacopo Mocci, CNR-Institute for Photonics and Nanotechnology (Italy)
Suman Manna, Univ. of California, Davis (United States)
Ratheesh K. Meleppat, Univ. of California, Davis (United States)
Stefano Bonora, CNR-Institute for Photonics and Nanotechnology (Italy)
Marinko V. Sarunic, Simon Fraser Univ. (Canada)
Edward N. Pugh, Univ. of California, Davis (United States)
Robert J. Zawadzki, Univ. of California, Davis (United States)


Published in SPIE Proceedings Vol. 10474:
Ophthalmic Technologies XXVIII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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