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Proceedings Paper

Mid-infrared fiber-coupled supercontinuum spectroscopic imaging using a tapered chalcogenide photonic crystal fiber
Author(s): Christian Rosenberg Petersen; Nikola Prtljaga; Mark Farries; Jon Ward; Bruce Napier; Gavin Rhys Lloyd; Jayakrupakar Nallala; Nick Stone; Ole Bang
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Paper Abstract

We present the first demonstration of mid-infrared spectroscopic imaging of human tissue using a fiber-coupled supercontinuum source spanning from 2-7.5 μm. The supercontinuum was generated in a tapered large mode area chalcogenide photonic crystal fiber in order to obtain broad bandwidth, high average power, and single-mode output for good imaging properties. Tissue imaging was demonstrated in transmission by raster scanning over a sub-mm region of paraffinized colon tissue on CaF2 substrate, and the signal was measured using a fiber-coupled grating spectrometer. This demonstration has shown that we can distinguish between epithelial and surrounding connective tissues within a paraffinized section of colon tissue by imaging at discrete wavelengths related to distinct chemical absorption features.

Paper Details

Date Published: 19 February 2018
PDF: 6 pages
Proc. SPIE 10489, Optical Biopsy XVI: Toward Real-Time Spectroscopic Imaging and Diagnosis, 1048905 (19 February 2018); doi: 10.1117/12.2288541
Show Author Affiliations
Christian Rosenberg Petersen, DTU Fotonik (Denmark)
Nikola Prtljaga, Gooch & Housego Ltd. (United Kingdom)
Mark Farries, Gooch & Housego Ltd. (United Kingdom)
Jon Ward, Gooch & Housego Ltd. (United Kingdom)
Bruce Napier, Vivid Components Ltd. (Germany)
Gavin Rhys Lloyd, NHS Foundation Trust (United Kingdom)
Jayakrupakar Nallala, Univ. of Exeter (United Kingdom)
Nick Stone, Univ. of Exeter (United Kingdom)
Ole Bang, DTU Fotonik (Denmark)
NKT Photonics A/S (Denmark)

Published in SPIE Proceedings Vol. 10489:
Optical Biopsy XVI: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos, Editor(s)

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