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Proceedings Paper

Evaluation of microvascular disturbances in rheumatic diseases by analysis of skin blood flow oscillations
Author(s): Irina N. Makovik; Viktor V. Dremin; Angelina I. Zherebtsova; Alexander I. Krupatkin; Lyudmila S. Khakhicheva; Vadim F. Muradyan; Igor V. Meglinski; Andrey V. Dunaev
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Paper Abstract

Laser Doppler flowmetry (LDF), tissue reflectance oximetry (TRO) and pulse oximetry (PO) and cold pressor test (CPT) were used to assess the microcirculation parameters and the activation of regulatory mechanisms. LDF and TRO samples wavelet transform in the frequency bands 0.01-2 Hz was used to evaluate microvascular disturbances in rheumatic diseases and to assess the vascular involvement in the pathological process. The spectral components of LDF and TRO signals associated with endothelial, adrenergic, intrinsic smooth muscle, respiratory and cardiac activities were analyzed. Significant difference between healthy and rheumatology subjects was identified in perfusion parameters. Spectral analysis of the LDF signal revealed significant difference between two group of high (<0.1 Hz) frequency pulsations. Based on the analysed of the perfusion and amplitudes oscillation in the frequency band the decision rule for detection microvascular disturbances were synthesized. The perfusion parameter and amplitude oscillation associated with cardiac activities included in the decision rule. Based on the measured parameters and the result of wavelet transform LDF- and TRO-signals the parameters for detection of complications associated with microvascular disturbances and their possible causes were proposed..

Paper Details

Date Published: 17 May 2018
PDF: 7 pages
Proc. SPIE 10685, Biophotonics: Photonic Solutions for Better Health Care VI, 106854S (17 May 2018); doi: 10.1117/12.2288239
Show Author Affiliations
Irina N. Makovik, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Viktor V. Dremin, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Univ. of Oulu (Finland)
Angelina I. Zherebtsova, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Alexander I. Krupatkin, Central Scientific-Research Institute of Traumatology and Orthopedics, n.n. Priorova (Russian Federation)
Lyudmila S. Khakhicheva, Orel Regional Clinical Hospital (Russian Federation)
Vadim F. Muradyan, Orel Regional Clinical Hospital (Russian Federation)
Igor V. Meglinski, Univ. of Oulu (Finland)
Orel State Univ. names after I.S. Turgenev (Russian Federation)
Andrey V. Dunaev, Orel State Univ. named after I.S. Turgenev (Russian Federation)


Published in SPIE Proceedings Vol. 10685:
Biophotonics: Photonic Solutions for Better Health Care VI
Jürgen Popp; Valery V. Tuchin; Francesco Saverio Pavone, Editor(s)

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