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A dynamic system with digital lock-in-photon-counting for pharmacokinetic diffuse fluorescence tomography
Author(s): Guoyan Yin; Limin Zhang; Yanqi Zhang; Han Liu; Wenwen Du; Wenjuan Ma; Huijuan Zhao; Feng Gao
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Paper Abstract

Pharmacokinetic diffuse fluorescence tomography (DFT) can describe the metabolic processes of fluorescent agents in biomedical tissue and provide helpful information for tumor differentiation. In this paper, a dynamic DFT system was developed by employing digital lock-in-photon-counting with square wave modulation, which predominates in ultra-high sensitivity and measurement parallelism. In this system, 16 frequency-encoded laser diodes (LDs) driven by self-designed light source system were distributed evenly in the imaging plane and irradiated simultaneously. Meanwhile, 16 detection fibers collected emission light in parallel by the digital lock-in-photon-counting module. The fundamental performances of the proposed system were assessed with phantom experiments in terms of stability, linearity, anti-crosstalk as well as images reconstruction. The results validated the availability of the proposed dynamic DFT system.

Paper Details

Date Published: 19 February 2018
PDF: 9 pages
Proc. SPIE 10486, Design and Quality for Biomedical Technologies XI, 1048613 (19 February 2018); doi: 10.1117/12.2287821
Show Author Affiliations
Guoyan Yin, Tianjin Univ. (China)
Limin Zhang, Tianjin Univ. (China)
Yanqi Zhang, Tianjin Univ. (China)
Han Liu, Tianjin Univ. (China)
Wenwen Du, Tianjin Univ. (China)
Wenjuan Ma, Tianjin Medical Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)


Published in SPIE Proceedings Vol. 10486:
Design and Quality for Biomedical Technologies XI
Ramesh Raghavachari; Rongguang Liang, Editor(s)

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