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A fast MEMS scanning photoacoustic microscopy system and its application in glioma study
Author(s): Renzhe Bi; Ghayathri Balasundaram; Seungwan Jeon; Yang Pu; Hui Chien Tay; Chulhong Kim; Malini Olivo
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Paper Abstract

We present a water-proof Microelectromechanical systems (MEMS) based scanning optical resolution Photoacoustic Microscopy (OR-PAM) system and its application in glioma tumor mouse model study. The presented OR-PAM system has high optical resolution (~3 μm) and high scanning speed (up to 50 kHz A-scan rate), which is ideal for cerebral vascular imaging. In this study, the mice with glioma tumor are treated with vascular disrupting agent (VDA). OR-PAM system is utilized to image the cerebral with the whole skull intact before and after the injection of VDA. By image registration, the response of every single blood vessel can be traced. This will provide us deeper understanding of the drug effect.

Paper Details

Date Published: 19 February 2018
PDF: 6 pages
Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104942I (19 February 2018); doi: 10.1117/12.2287330
Show Author Affiliations
Renzhe Bi, Singapore Bioimaging Consortium (Singapore)
Ghayathri Balasundaram, Singapore Bioimaging Consortium (Singapore)
Seungwan Jeon, Pohang Univ. of Science and Technology (Korea, Republic of)
Yang Pu, MicroPhotoAcoustics Inc. (United States)
Hui Chien Tay, Singapore Bioimaging Consortium (Singapore)
Chulhong Kim, Pohang Univ. of Science and Technology (Korea, Republic of)
Malini Olivo, Singapore Bioimaging Consortium (Singapore)


Published in SPIE Proceedings Vol. 10494:
Photons Plus Ultrasound: Imaging and Sensing 2018
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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