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Subretinal hyper-reflective material seen on optical coherence tomography as a biomarker for disease monitoring in age-related macular degeneration
Author(s): H. B. Lee; B. B. Ong; M. Katta; C. Yvon; L. Lu; R. Zakri; N. Patel
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Paper Abstract

Subretinal hyper-reflective material (SHRM) seen on optical coherence tomography (OCT) is thought to be a collection of fibrous tissues and vascular networks that are identified in age-related macular degeneration (ARMD). We have carried out a retrospective analysis of 91 OCT scans of neovascular ARMD subtypes including classic and occult choroidal neovascularization (CNV) and retinal angiomatous proliferation (RAP). All three subtypes received ranibizumab, an anti-vascular endothelial growth factor (Anti-VEGF) intravitreal injections on an as-needed basis following the loading doses. Volumes of SHRM were calculated using caliper measurements of maximal height and length of SHRM seen on OCT. The ellipsoid formula derived from tumour models was used to calculate the volume. It was found that occult CNV and RAP have larger SHRM volumes than those of classic CNV. SHRM volumes reduced overall following loading doses of Anti-VEGF injections at 4 months in all three subtypes. However, a rebound increase in volume was noticed in both occult CNV and RAP cohort at 12 months despite the initial, steeper reductions in the subtypes. These findings were consistent with the data seen in volume measurement using Topcon’s automated segmentation algorithm in a smaller cohort of patients. We propose that SHRM should be used as a potential biomarker to quantify both disease progression and prognosis of neovascular ARMD alongside other conventional methods.

Paper Details

Date Published: 5 March 2018
PDF: 7 pages
Proc. SPIE 10591, 2nd Canterbury Conference on OCT with Emphasis on Broadband Optical Sources, 1059103 (5 March 2018); doi: 10.1117/12.2287271
Show Author Affiliations
H. B. Lee, East Kent Hospitals Univ. NHS Foundation Trust (United Kingdom)
B. B. Ong, East Kent Hospitals Univ. NHS Foundation Trust (United Kingdom)
M. Katta, East Kent Hospitals Univ. NHS Foundation Trust (United Kingdom)
C. Yvon, East Kent Hospitals Univ. NHS Foundation Trust (United Kingdom)
L. Lu, East Kent Hospitals Univ. NHS Foundation Trust (United Kingdom)
R. Zakri, East Kent Hospitals Univ. NHS Foundation Trust (United Kingdom)
N. Patel, East Kent Hospitals Univ. NHS Foundation Trust (United Kingdom)
Kings College School of Medicine (United Kingdom)


Published in SPIE Proceedings Vol. 10591:
2nd Canterbury Conference on OCT with Emphasis on Broadband Optical Sources
Adrian Podoleanu; Ole Bang, Editor(s)

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