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Proceedings Paper

Quantification of NIRS data of a blood phantom by spectral multicomponent analysis
Author(s): Chongwu Du; Werner Nahm; Hartmut Gehring; Ewald Konecny
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Paper Abstract

In order to quantify the chromophore components from in vivo blood NIRS, a blood- equivalent phantom has been developed which consists of properly diluted intralipid and ICG dye. The reflection and transmission near infrared spectroscopy (NIRS) of the phantoms with different scattering backgrounds and ICG concentrations are measured and analyzed by the spectral multicomponent analysis (MCA) method to extract ICG concentration. The experimental results show that the MCA method can be used to quantify absolute ICG concentrations in scattering media if the average path lengths are known. Moreover, it was found by the experiments that both the water absorption peak at 970 nm and the ICG absorption peak at 800 nm show similar behavior during the change of the scattering background. Thus the ratio of the MCA-estimated concentration factor of ICG to water is independent of the blood-phantom scattering.

Paper Details

Date Published: 18 December 1995
PDF: 11 pages
Proc. SPIE 2626, Photon Propagation in Tissues, (18 December 1995); doi: 10.1117/12.228657
Show Author Affiliations
Chongwu Du, Medizinische Univ. zu Luebeck (Germany)
Werner Nahm, Medizinische Univ. zu Luebeck (Germany)
Hartmut Gehring, Medizinische Univ. zu Luebeck (Germany)
Ewald Konecny, Medizinische Univ. zu Luebeck (Germany)

Published in SPIE Proceedings Vol. 2626:
Photon Propagation in Tissues
Britton Chance; David T. Delpy; Gerhard J. Mueller, Editor(s)

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