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Proceedings Paper

In vivo near infrared (NIRS) sensor attachment using fibrin bioadhesive
Author(s): Andrew Macnab; Roberto Pagano; Brian Kwon; Guy Dumont; Babak Shadgan
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Paper Abstract

Background: ‘Tisseel’ (Baxter Healthcare, Deerfield, IL) is a fibrin-based sealant that is commonly used during spine surgery to augment dural repairs. We wish to intra-operatively secure a near infrared spectroscopy (NIRS) sensor to the dura in order to monitor the tissue hemodynamics of the underlying spinal cord. To determine if ‘Tisseel’ sealant adversely attenuates NIR photon transmission. Methods: We investigated ‘Tisseel’ in both an in vitro and in vivo paradigm. For in vitro testing, we used a 1 mm pathlength cuvette containing either air or ‘Tisseel’ interposed between a NIR light source (760 and 850 nm) and a photodiode detector and compared transmittance. For in vivo testing, a continuous wave (760 and 850 nm) spatiallyresolved NIRS device was placed over the triceps muscle using either conventional skin apposition (overlying adhesive bandage) or bioadhesion with ‘Tisseel’. Raw optical data and tissue saturation index (TSI%) collected at rest were compared. Results: In-vitro NIR light absorption by ‘Tisseel’ was very high, with transmittance reduced by 95% compared to air. In-vivo muscle TSI% values were 80% with conventional attachment and 20% using fibrin glue. Conclusion: The optical properties of ‘Tisseel’ significantly attenuate NIR light during in-vitro transmittance and critically compromise photon transmission in-vivo.

Paper Details

Date Published: 20 February 2018
PDF: 8 pages
Proc. SPIE 10501, Optical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics, 105010M (20 February 2018); doi: 10.1117/12.2286563
Show Author Affiliations
Andrew Macnab, Stellenbosch Institute for Advanced Study (South Africa)
Roberto Pagano, The Univ. of British Columbia (Canada)
Brian Kwon, International Collaboration On Repair Discoveries (Canada)
The Univ. of British Columbia (Canada)
Guy Dumont, The Univ. of British Columbia (Canada)
Babak Shadgan, International Collaboration On Repair Discoveries (Canada)
The Univ. of British Columbia (Canada)

Published in SPIE Proceedings Vol. 10501:
Optical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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