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Proceedings Paper

Non-invasive detection of matrix-metalloproteinase activity in a mouse model of cerebral ischemia using multispectral optoacoustic tomography
Author(s): Ruiqing Ni; Markus Vaas; Wuwei Ren; Jan Klohs
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Paper Abstract

Matrix metalloproteinases (MMPs) play important roles in the pathophysiology of cerebral ischemia. Here we visualized in vivo MMP activity in the transient middle cerebral artery occlusion (tMCAO) mouse model using multispectral optoacoustic imaging (MSOT) with a MMP-activatable probe. MSOT data was co-registered with structural magnetic resonance imaging (MRI) obtained at 7 T for localization of signal distribution. We demonstrated upregulated MMP signal within the focal ischemic lesion in the tMCAO mouse model using MSOT/MRI multimodal imaging. This convenient non-invasive method will allow repetitive measurement following the time course of MMP-lesion development in ischemic stroke animal model.

Paper Details

Date Published: 19 February 2018
PDF: 6 pages
Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104940O (19 February 2018); doi: 10.1117/12.2286313
Show Author Affiliations
Ruiqing Ni, Univ. Zürich (Switzerland)
ETH Zurich (Switzerland)
Markus Vaas, Univ. Zürich (Switzerland)
ETH Zurich (Switzerland)
Wuwei Ren, Univ. Zürich (Switzerland)
ETH Zurich (Switzerland)
Jan Klohs, Univ. Zürich (Switzerland)
ETH Zurich (Switzerland)

Published in SPIE Proceedings Vol. 10494:
Photons Plus Ultrasound: Imaging and Sensing 2018
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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