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Proceedings Paper

Observation of rat’s colon polyps in real time by mini-endoscopy and raman spectroscopy
Author(s): Bibin Bintang Andriana; Anggara Mahardika; Akinori Taketani; Hidetoshi Sato
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Paper Abstract

Colorectal adenoma (CA) is a disease caused by various factors (such as genetic factors or environmental exposures). The appearance of colon polyp (CP) within colorectal might indicate the hint of CA development. Ball-lens hollow fiber Raman probe (BHRP) may has a high capability for detection of CA in living experimental animal and have already tested to rat’s CP in this study, which was designed to collaborate between BHRP with mini-endoscopy to observe the biochemical alteration within normal colon tissue and rat’s colon polyps in real time. BHRP and mini-endoscopy can distinguish the differences in their finger print spectra and make pictures the control and CP in the real time. At the first step, the real situation of normal colon and Rat’s CP were washed by saline and observed with mini-endoscopy. BHRP was introduced to Dextran sodium sulphate (DSS)-induced Rat's CP to detect some of biochemical alteration. The main purpose of this study was to introduce mini-endoscopy to guide the BHRP for diagnosing of CP in real time and to compare it with spectra of normal colon (control group) in living rat. As the result, BHRP can provide the differences in band of control and CP group, which can inform that the biochemical of normal and CP has changed. As a major parameter to distinct normal and CP tissue were phosphatidylinositol, phosphodiester group, lipid, and collagen. Mini endoscopy and BHRP is very sensitive devices for diagnosing of CP in real time.

Paper Details

Date Published: 14 February 2018
PDF: 7 pages
Proc. SPIE 10470, Endoscopic Microscopy XIII, 104701A (14 February 2018); doi: 10.1117/12.2286244
Show Author Affiliations
Bibin Bintang Andriana, Kwansei Gakuin Univ. (Japan)
Anggara Mahardika, Kwansei Gakuin Univ. (Japan)
Akinori Taketani, Kwansei Gakuin Univ. (Japan)
Hidetoshi Sato, Kwansei Gakuin Univ. (Japan)

Published in SPIE Proceedings Vol. 10470:
Endoscopic Microscopy XIII
Guillermo J. Tearney; Thomas D. Wang; Melissa J. Suter, Editor(s)

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