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Assessment of the status of onchocerciasis worms with DRS: proposal of a standardized measurement protocol
Author(s): Anne Planat-Chrétien; M. Berger; Samuel Wanji; Michel Boussinesq; Belen Pedrique; Jean-Marc Dinten
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Paper Abstract

In the present work, we show the capacity of spatially resolved Diffuse Reflectance Spectroscopy (DRS) to identify live and dead worms in ex vivo Onchocerca ochengi nodules. It demonstrates the potential of DRS to diagnose the worm state and to monitor the effect of a drug on macrofilariae. These results have been obtained in constrained conditions, leading to the proposal of a rigorous acquisition and analysis protocol that may contribute to standardized measures in diffuse optics.

Paper Details

Date Published: 28 July 2017
PDF: 4 pages
Proc. SPIE 10412, Diffuse Optical Spectroscopy and Imaging VI, 104120I (28 July 2017); doi: 10.1117/12.2286051
Show Author Affiliations
Anne Planat-Chrétien, CEA-LETI (France)
M. Berger, CEA-LETI (France)
Samuel Wanji, Univ. of Buea (Cameroon)
Michel Boussinesq, Institut de Recherche pour le Développement (France)
Belen Pedrique, Drugs for Neglected Diseases Initiative (Switzerland)
Jean-Marc Dinten, CEA-LETI (France)


Published in SPIE Proceedings Vol. 10412:
Diffuse Optical Spectroscopy and Imaging VI
Hamid Dehghani; Heidrun Wabnitz, Editor(s)

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