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Proceedings Paper

Analysis of hemodynamics in human skin using photothermal radiometry and diffuse reflectance spectroscopy
Author(s): Nina Verdel; Ana Marin; Luka Vidovič; Matija Milanič; Boris Majaron
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Paper Abstract

We present a novel methodology for quantitative analysis of hemodynamics in human skin in vivo. Our approach combines pulsed photothermal radiometry (i.e., time-resolved measurements of midinfrared emission from sample surface after exposure to a short light pulse) and diffuse reflectance spectroscopy in visible part of the spectrum. Experimental data are fitted with predictions of a numerical model of light transport in a four-layer skin model (i.e., inverse Monte Carlo), which allows assessment of the layer thicknesses, chromophore contents (e.g., melanin, oxy- and deoxy-hemoglobin), as well as scattering properties. The performance is tested in comparison analysis of healthy skin before and during application of a blood pressure cuff (at 200 mm Hg) for 5 minutes.

Paper Details

Date Published: 28 July 2017
PDF: 10 pages
Proc. SPIE 10413, Novel Biophotonics Techniques and Applications IV, 104130O (28 July 2017); doi: 10.1117/12.2286043
Show Author Affiliations
Nina Verdel, Jožef Stefan Institute (Slovenia)
Ana Marin, Univ. of Ljubljana (Slovenia)
Luka Vidovič, Jožef Stefan Institute (Slovenia)
Matija Milanič, Jožef Stefan Institute (Slovenia)
Univ. of Ljubljana (Slovenia)
Boris Majaron, Jožef Stefan Institute (Slovenia)
Univ. of Ljubljana (Slovenia)


Published in SPIE Proceedings Vol. 10413:
Novel Biophotonics Techniques and Applications IV
Arjen Amelink; I. Alex Vitkin, Editor(s)

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