Share Email Print
cover

Proceedings Paper

Contrast-enhanced photoacoustic imaging with an optical wavelength of 1064 nm
Author(s): Jeesu Kim; Sara Park; Gyeong Bae Park; Wonseok Choi; Unyong Jeong; Chulhong Kim
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Photoacoustic (PA) imaging is a biomedical imaging method that can provide both structural and functional information of living tissues beyond the optical diffusion limit by combining the concepts of conventional optical and ultrasound imaging methods. Although endogenous chromophores can be utilized to acquire PA images of biological tissues, exogenous contrast agents that absorb near-infrared (NIR) lights have been extensively explored to improve the contrast and penetration depth of PA images. Here, we demonstrate Bi2Se3 nanoplates, that strongly absorbs NIR lights, as a contrast agent for PA imaging. In particularly, the Bi2Se3 nanoplates produce relatively strong PA signals with an optical wavelength of 1064 nm, which has several advantages for deep tissue imaging including: (1) relatively low absorption by other intrinsic chromophores, (2) cost-effective light source using Nd:YAG laser, and (3) higher available energy than other NIR lights according to American National Standards Institute (ANSI) safety limit. We have investigated deep tissue imaging capability of the Bi2Se3 nanoplates by acquiring in vitro PA images of microtubes under chicken breast tissues. We have also acquired in vivo PA images of bladders, gastrointestinal tracts, and sentinel lymph nodes in mice after injection of the Bi2Se3 nanoplates to verify their applicability to a variety of biomedical research. The results show the promising potential of the Bi2Se3 nanoplates as a PA contrast agent for deep tissue imaging with an optical wavelength of 1064 nm.

Paper Details

Date Published: 19 February 2018
PDF: 6 pages
Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104944I (19 February 2018); doi: 10.1117/12.2286012
Show Author Affiliations
Jeesu Kim, Pohang Univ. of Science and Technology (Korea, Republic of)
Sara Park, Pohang Univ. of Science and Technology (Korea, Republic of)
Gyeong Bae Park, Pohang Univ. of Science and Technology (Korea, Republic of)
Wonseok Choi, Pohang Univ. of Science and Technology (Korea, Republic of)
Unyong Jeong, Pohang Univ. of Science and Technology (Korea, Republic of)
Chulhong Kim, Pohang Univ. of Science and Technology (Korea, Republic of)


Published in SPIE Proceedings Vol. 10494:
Photons Plus Ultrasound: Imaging and Sensing 2018
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

© SPIE. Terms of Use
Back to Top