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Laser speckle imaging of brain blood flow through a transparent nanocrystalline yttria-stabilized-zirconia cranial implant
Author(s): Nami Davoodzadeh; David Halaney; Carrie R. Jonak; Natanael Cuando; Amirhessam Aminfar; Devin K. Binder; Guillermo Aguilar
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Paper Abstract

The laser speckle flowmetry methods based on laser speckle imaging (LSI) have attracted extensive attention recently because they can image brain blood flow with high spatiotemporal resolution. However, the poor transparency of the cranial bone limits the spatial resolution and the imaging depth. This problem has previously been addressed in animal studies by removing or thinning the skull to transparency. Nevertheless, a permanent and reliable solution has not yet been developed. Our study demonstrates a new method to address this challenge in biomedical imaging research, through the use of novel transparent cranial implants made from nanocrystalline yttria-stabilized zirconia (nc-YSZ). By applying LSI to underlying brain in an acute murine model, we show that spatial resolution and quantitative accuracy of blood flow measurement are improved when imaging through transparent nc-YSZ implants relative to native cranium. As such, these results provide the initial evidence supporting the feasibility of nc-YSZ transparent cranial implant as a clinically-viable long-term optical access for LSI on a chronically-recurring basis, thereby suppressing the need for repeated craniotomies. Successful development of this method has the potential to advance the study of neuropathologies or novel neuro-procedures in animal models where measurement of cerebral blood flow is of interest, such as blood flow changes during stroke, changes in blood flow due to functional activation, and spreading depolarization and its role in brain injuries, pathophysiology of migraine, and subarachnoid hemorrhage.

Paper Details

Date Published: 13 February 2018
PDF: 7 pages
Proc. SPIE 10493, Dynamics and Fluctuations in Biomedical Photonics XV, 1049303 (13 February 2018); doi: 10.1117/12.2285953
Show Author Affiliations
Nami Davoodzadeh, Univ. of California, Riverside (United States)
David Halaney, Univ. of California, Riverside (United States)
Carrie R. Jonak, School of Medicine, Univ. of California, Riverside (United States)
Natanael Cuando, Univ. of California, Riverside (United States)
Amirhessam Aminfar, Univ. of California, Riverside (United States)
Devin K. Binder, School of Medicine, Univ. of California, Riverside (United States)
Guillermo Aguilar, Univ. of California, Riverside (United States)

Published in SPIE Proceedings Vol. 10493:
Dynamics and Fluctuations in Biomedical Photonics XV
Valery V. Tuchin; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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