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A lymphocyte spatial distribution graph-based method for automated classification of recurrence risk on lung cancer images
Author(s): Juan D. Garciá-Arteaga; Germán Corredor; Xiangxue Wang; Vamsidhar Velcheti; Anant Madabhushi; Eduardo Romero
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Paper Abstract

Tumor-infiltrating lymphocytes occurs when various classes of white blood cells migrate from the blood stream towards the tumor, infiltrating it. The presence of TIL is predictive of the response of the patient to therapy. In this paper, we show how the automatic detection of lymphocytes in digital H and E histopathological images and the quantitative evaluation of the global lymphocyte configuration, evaluated through global features extracted from non-parametric graphs, constructed from the lymphocytes’ detected positions, can be correlated to the patient’s outcome in early-stage non-small cell lung cancer (NSCLC). The method was assessed on a tissue microarray cohort composed of 63 NSCLC cases. From the evaluated graphs, minimum spanning trees and K-nn showed the highest predictive ability, yielding F1 Scores of 0.75 and 0.72 and accuracies of 0.67 and 0.69, respectively. The predictive power of the proposed methodology indicates that graphs may be used to develop objective measures of the infiltration grade of tumors, which can, in turn, be used by pathologists to improve the decision making and treatment planning processes.

Paper Details

Date Published: 17 November 2017
PDF: 7 pages
Proc. SPIE 10572, 13th International Conference on Medical Information Processing and Analysis, 1057203 (17 November 2017); doi: 10.1117/12.2285653
Show Author Affiliations
Juan D. Garciá-Arteaga, Univ. Nacional de Colombia (Colombia)
Germán Corredor, Univ. Nacional de Colombia (Colombia)
Case Western Reserve Univ. (United States)
Xiangxue Wang, Case Western Reserve Univ. (United States)
Vamsidhar Velcheti, Cleveland Clinic Foundation (United States)
Anant Madabhushi, Case Western Reserve Univ. (United States)
Eduardo Romero, Univ. Nacional de Colombia (Colombia)


Published in SPIE Proceedings Vol. 10572:
13th International Conference on Medical Information Processing and Analysis
Eduardo Romero; Natasha Lepore; Jorge Brieva; Juan David García, Editor(s)

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