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Real-time three-dimensional temperature mapping in photothermal therapy with optoacoustic tomography
Author(s): Francisco Javier Oyaga Landa; Xosé Luís Deán-Ben; Ronald Sroka; Daniel Razansky
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Paper Abstract

Ablation and photothermal therapy are widely employed medical protocols where the selective destruction of tissue is a necessity as in cancerous tissue removal or vascular and brain abnormalities. Tissue denaturation takes place when the temperature reaches a threshold value while the time of exposure determines the lesion size. Therefore, the spatio-temporal distribution of temperature plays a crucial role in the outcome of these clinical interventions. We demonstrate fast volumetric temperature mapping with optoacoustic tomography based on real-time optoacoustic readings from the treated region. The performance of the method was investigated in tissue-mimicking phantom experiments. The new ability to non-invasively measure temperature volumetrically in an entire treated region with high spatial and temporal resolutions holds potential for improving safety and efficacy of thermal ablation and to advance the general applicability of laser-based therapy.

Paper Details

Date Published: 1 August 2017
PDF: 7 pages
Proc. SPIE 10415, Opto-Acoustic Methods and Applications in Biophotonics III, 104150A (1 August 2017); doi: 10.1117/12.2285568
Show Author Affiliations
Francisco Javier Oyaga Landa, Helmholtz Zentrum München (Germany)
Technical Univ. of Munich (Germany)
Xosé Luís Deán-Ben, Helmholtz Zentrum München (Germany)
Ronald Sroka, Ludwig-Maximilian-Univ. München (Germany)
Daniel Razansky, Helmholtz Zentrum München (Germany)
Technical Univ. of Munich (Germany)


Published in SPIE Proceedings Vol. 10415:
Opto-Acoustic Methods and Applications in Biophotonics III
Vasilis Ntziachristos; Roger Zemp, Editor(s)

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