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In vivo imaging of colonic tumours with a near-infrared fluorescent probe targeted against a tumour-associated-mucin in a human colon cancer xenograft mouse model
Author(s): Ralph S. DaCosta
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Paper Abstract

Purpose: Conventional endoscopic imaging in human colon detects large hyperplastic and adenomatous polyps (<5mm diam). However, detecting smaller early neoplastic lesions and flat adenomas is problematic. To improve the detection of such lesions we assessed the utility of fluorescence contrast agents for enhancing contrast between normal and abnormal tissues. To this end, a near infrared (NIR) fluorescent dye conjugated to a monoclonal antibody (MAb) with high affinity for a tumour-associated-glycoprotein (TAG72) antigen commonly found in colon tumours was studied as a potential fluorescence contrast agent.

Paper Details

Date Published: 29 August 2017
PDF: 2 pages
Proc. SPIE 10313, Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging, 1031334 (29 August 2017); doi: 10.1117/12.2283908
Show Author Affiliations
Ralph S. DaCosta, Ontario Cancer Institute (Canada)


Published in SPIE Proceedings Vol. 10313:
Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging
John C. Armitage, Editor(s)

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