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Proceedings Paper

NADH fluorimetry and diffuse reflectance spectroscopy on rat heart
Author(s): J. M. C. C. Coremans
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Paper Abstract

The ability to assess the adequacy of oxygen delivery by the circulation to the mitochondria in tissue is essential in surgery, intensive care and anaesthesia. Furthermore it has become increasingly clear that it is no longer sufficient to measure global oxygen delivery and consumption as indicators of metabolic requirements but that knowledge about local oxygenation is needed. This is due to the redistribution of oxygen delivery and consumption between and even within the different organs. The success of the recently introduced tonometry, using splanchnic oxygenation instead of global oxygen parameters, as a guide to therapy in critical care [Fiddian-Green '87, Guterriez '92] is witness to the importance of the need to obtain information about the course of oxygen to tissue at microcirculatory and even mitochondrial level.

Paper Details

Date Published: 5 August 1993
PDF: 29 pages
Proc. SPIE 10311, Medical Optical Tomography: Functional Imaging and Monitoring, 1031110 (5 August 1993); doi: 10.1117/12.2283781
Show Author Affiliations
J. M. C. C. Coremans, Erasmus Univ. (Netherlands)

Published in SPIE Proceedings Vol. 10311:
Medical Optical Tomography: Functional Imaging and Monitoring
Gerhard J. Mueller, Editor(s)

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