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Proceedings Paper

The physical basis of biomedical optical imaging using time-dependent measurements of photon migration in the frequency-domain
Author(s): E. M. Sevick
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Paper Abstract

A physical model of how optical heterogeneities affect time-dependent measurements of photon migration in tissue-like scattering media is presented. Using this model, changes in frequency-domain measurements of phase-shift, 0, and amplitude modulation, M, are predicted in the presence of transparent and perfectly absorbing objects. Two-dimensional Monte Carlo simulations of photon migration and single-pixel measurements of 0 and M confirm the physical model. Recent experimental "images" from multi-pixel measurements of 0 and M are also consistent with the physical model. These results suggest that two dimensional frequency-domain measurements provide direct information for detection and three dimensional localization of optical heterogeneities without the use of computer intensive reconstruction algorithms.

Paper Details

Date Published: 5 August 1993
PDF: 28 pages
Proc. SPIE 10311, Medical Optical Tomography: Functional Imaging and Monitoring, 103110T (5 August 1993); doi: 10.1117/12.2283774
Show Author Affiliations
E. M. Sevick, Vanderbilt Univ. (United States)


Published in SPIE Proceedings Vol. 10311:
Medical Optical Tomography: Functional Imaging and Monitoring
Gerhard J. Mueller, Editor(s)

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