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Proceedings Paper

On the physical rationale of photodynamic therapy
Author(s): Lars O. Svaasand
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Paper Abstract

The physical principles of dosimetry for photodynamic therapy are discussed. The presentation emphasizes a discussion of prognosticated maximum obtainable depth of tumor necrosis and of expected maximum depth of selective necrosis, i.e. the maximum depth which can be obtained before normal tissue within the light field at the surface is destroyed at the same rate as the neoplastic cells at the given depth into the tumor. These parameters are discussed in terms of bleaching, retention and clearance of the photosensitizer and of optical properties of the tissue.

Paper Details

Date Published: 21 January 1990
PDF: 16 pages
Proc. SPIE 10306, Future Directions and Applications in Photodynamic Therapy, 103060I (21 January 1990); doi: 10.1117/12.2283680
Show Author Affiliations
Lars O. Svaasand, Norwegian Univ. of Science and Technology (Norway)


Published in SPIE Proceedings Vol. 10306:
Future Directions and Applications in Photodynamic Therapy
Charles J. Gomer, Editor(s)

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