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Proceedings Paper

New approaches to photochemotherapy: cationic sensitizers and multi-agent combination therapies
Author(s): Allan R. Oseroff
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Paper Abstract

"Second generation" photochemotherapies might employ a multiagent approach using cationic photosensitizers which selectively target tumor cells together with anionic photosensitizers which act on blood vessels. Combination photochemotherapies might also include glycolysis inhibitors and/or hyperthermia to rationally enhance light-induced killing and still maintain tumor selectivity. Some unresolved issues are also discussed: We generally do not understand the biological bases for tumor selectivity and photochemotherapeutic efficacy. We need to determine the desirability of absolute malignant cell specificity. Both in vitro and in vivo test systems should be improved and standardized, and their (ir)relevance to clinical PCT carefully examined. More mechanistic data should be obtained from ongoing and future clinical trials. Finally, we need to better define the critical biochemical and cellular mechanisms of cell injury and death, and better understand why therapy fails.

Paper Details

Date Published: 21 January 1990
PDF: 18 pages
Proc. SPIE 10306, Future Directions and Applications in Photodynamic Therapy, 103060E (21 January 1990); doi: 10.1117/12.2283676
Show Author Affiliations
Allan R. Oseroff, Roswell Park Cancer Institute (United States)

Published in SPIE Proceedings Vol. 10306:
Future Directions and Applications in Photodynamic Therapy
Charles J. Gomer, Editor(s)

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