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Proceedings Paper

The significance of vascular photosensitization in photodynamic therapy
Author(s): Barbara W. Henderson
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Paper Abstract

Past research has shown that photodynamic therapy, using Photofrin II as sensitizer, exerts its tumor-destructive effects primarily through assault on the tissue microvasculature. This is accompanied by less than optimal treatment selectivity and prolonged normal tissue photo- sensitivity. The development of new sensitizers should therefore add to its goals of finding improved photochemical and photophysical characteristics the goal of increased tumor selectivity. The latter can only be achieved through detailed comparative studies of different second generation sensitizers, which will serve to unravel structure/function relationships and so lead to the rational design of new and truly superior compounds.

Paper Details

Date Published: 21 January 1990
PDF: 14 pages
Proc. SPIE 10306, Future Directions and Applications in Photodynamic Therapy, 103060C (21 January 1990); doi: 10.1117/12.2283674
Show Author Affiliations
Barbara W. Henderson, Roswell Park Cancer Institute (United States)

Published in SPIE Proceedings Vol. 10306:
Future Directions and Applications in Photodynamic Therapy
Charles J. Gomer, Editor(s)

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