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Proceedings Paper

Basic mechanisms and subcellular targets related to PDT
Author(s): Charles J. Gomer
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Paper Abstract

The continued examination of injury sites and mechanisms of cytotoxicity associated with photodynamic therapy (PDT) can take advantage of current molecular and/or biochemical techniques. The increased expression of oxidative stress proteins can be studied as a function of photosensitizer type, treatment conditions and cell type. However, while in-vitro studies can address questions regarding subcellular PDT targets there is growing evidence that in-vivo effects of PDT are mediated by both vascular and direct tumor cell injury. Preclinical PDT studies using mono-l-aspartyl chlorin e6 (NPe6) confirm that the efficacy of this photosensitizer is correlated with plasma levels of this compound and not tumor cell levels.

Paper Details

Date Published: 21 January 1990
PDF: 14 pages
Proc. SPIE 10306, Future Directions and Applications in Photodynamic Therapy, 103060B (21 January 1990); doi: 10.1117/12.2283673
Show Author Affiliations
Charles J. Gomer, Children's Hospital Los Angeles (United States)

Published in SPIE Proceedings Vol. 10306:
Future Directions and Applications in Photodynamic Therapy
Charles J. Gomer, Editor(s)

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