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Proceedings Paper

Photosensitization with deep red light
Author(s): Michael A. J. Rodgers
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Paper Abstract

This paper concerns the use of deep-red light absorbing chromophores as potential photosensitizers for photodynamic therapy (PDT). In setting the scene, the role of scattering by tissues and of the availability of convenient laser light sources are considered. In terms of long wavelength extremes for the production of singlet oxygen, it is pointed out that the energy gap between S1 and T1 (EST) is the critical factor. Some of the photophysical and photochemical properties of naphthalocyanines and octabutoxyphthalocyanines are presented. Both species absorb strongly at 740 nm and beyond. Finally, the tissue distribution and phototherapeutic effectiveness in animal tumor models is outlined. Delivered doses as low as 0.5 mg/kg body weight are optimally effective.

Paper Details

Date Published: 21 January 1990
PDF: 12 pages
Proc. SPIE 10306, Future Directions and Applications in Photodynamic Therapy, 103060A (21 January 1990); doi: 10.1117/12.2283672
Show Author Affiliations
Michael A. J. Rodgers, Bowling Green State Univ. (United States)

Published in SPIE Proceedings Vol. 10306:
Future Directions and Applications in Photodynamic Therapy
Charles J. Gomer, Editor(s)

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