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Proceedings Paper

Second generation sensitizers: where are we and where should we be going?
Author(s): Alan R. Morgan
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Paper Abstract

In recent years, a number of new photosensitizers have been proposed as alternatives to Photofrin II, for use in photodynamic therapy. Most studies in this area have targeted the absorption characteristics of the photosensitizer as the important parameter however there is currently no general consensus on where this absorption should be. In this article, the spectroscopic requirements for photodynamic therapy are examined with respect to generation of phototoxic species, penetration of light through tissues, tumor location and compatibility with available light sources. Finally, additional properties which may dictate the choice of sensitizer, such as stability, purity, hydrophobicity and biological lifetime are discussed.

Paper Details

Date Published: 21 January 1990
PDF: 20 pages
Proc. SPIE 10306, Future Directions and Applications in Photodynamic Therapy, 1030607 (21 January 1990); doi: 10.1117/12.2283669
Show Author Affiliations
Alan R. Morgan, The Univ. of Toledo (United States)


Published in SPIE Proceedings Vol. 10306:
Future Directions and Applications in Photodynamic Therapy
Charles J. Gomer, Editor(s)

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