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Proceedings Paper

Optical coherence tomography of lymphatic vessel endothelial hyaluronan receptors in vivo
Author(s): Peng Si; Debasish Sen; Rebecca Dutta; Siavash Yousefi; Roopa Dalal; Yonatan Winetraub; Orly Liba; Adam de la Zerda
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Paper Abstract

Optical Coherence Tomography (OCT) imaging of living subjects offers millimeters depth of penetration into tissue while maintaining high spatial resolution. However, because most molecular biomarkers do not produce inherent OCT contrast signals, exogenous contrast agents must be employed to achieve molecular imaging. Here we demonstrate that microbeads (μBs) can be used as effective contrast agents to target cellular biomarkers in lymphatic vessels and can be detected by OCT using a phase variance algorithm. We applied this technique to image the molecular dynamics of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) in vivo, which showed significant down-regulation during tissue inflammation.

Paper Details

Date Published: 14 February 2018
PDF: 7 pages
Proc. SPIE 10483, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII, 1048326 (14 February 2018); doi: 10.1117/12.2282890
Show Author Affiliations
Peng Si, Stanford Univ. School of Medicine (United States)
Debasish Sen, Stanford Univ. School of Medicine (United States)
Rebecca Dutta, Stanford Univ. School of Medicine (United States)
Siavash Yousefi, Stanford Univ. School of Medicine (United States)
Roopa Dalal, Stanford Univ. School of Medicine (United States)
Yonatan Winetraub, Stanford Univ. School of Medicine (United States)
Orly Liba, Stanford Univ. School of Medicine (United States)
Adam de la Zerda, Stanford Univ. School of Medicine (United States)


Published in SPIE Proceedings Vol. 10483:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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