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Proceedings Paper

A framework for optimizing micro-CT in dual-modality micro-CT/XFCT small-animal imaging system
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Paper Abstract

Dual-modality Computed Tomography (CT)/X-ray Fluorescence Computed Tomography (XFCT) can be a valuable tool for imaging and quantifying the organ and tissue distribution of small concentrations of high atomic number materials in small-animal system. In this work, the framework for optimizing the micro-CT imaging system component of the dual-modality system is described, either when the micro-CT images are concurrently acquired with XFCT and using the x-ray spectral conditions for XFCT, or when the micro-CT images are acquired sequentially and independently of XFCT. This framework utilizes the cascaded systems analysis for task-specific determination of the detectability index using numerical observer models at a given radiation dose, where the radiation dose is determined using Monte Carlo simulations.

Paper Details

Date Published: 7 September 2017
PDF: 7 pages
Proc. SPIE 10393, Radiation Detectors in Medicine, Industry, and National Security XVIII, 103930R (7 September 2017); doi: 10.1117/12.2279351
Show Author Affiliations
Srinivasan Vedantham, The Univ. of Arizona (United States)
Suman Shrestha, Univ. of Massachusetts Medical School (United States)
Andrew Karellas, The Univ. of Arizona (United States)
Sang Hyun Cho, The Univ. of Texas MD Anderson Cancer Ctr. (United States)

Published in SPIE Proceedings Vol. 10393:
Radiation Detectors in Medicine, Industry, and National Security XVIII
Gary P. Grim; Lars R. Furenlid; H. Bradford Barber, Editor(s)

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