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Nanoscale holographic tomography of heart tissue with x-ray waveguide optics
Author(s): M. Reichardt; J. Frohn; M. Töpperwien; J.-D. Nicolas; A. Markus; F. Alves; T. Salditt
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Paper Abstract

In this work we present x-ray phase-contrast tomography of heart tissue from mouse, combining computed tomography (CT) scans with laboratory and synchrotron radiation. The work serves as a proof-of-concept that the cyto-architecture and in particular the myofibril orientation can be assessed in three dimensions (3D) by phase-contrast CT. We demonstrate the synergistic use of laboratory μ-CT and of the high resolution synchrotron setup based on waveguide optics. Details on preparation, instrumentation and analysis are given, as a state of the art reference for heart tissue tomography, and as a starting point for further progress.

Paper Details

Date Published: 19 September 2017
PDF: 12 pages
Proc. SPIE 10391, Developments in X-Ray Tomography XI, 1039105 (19 September 2017); doi: 10.1117/12.2276648
Show Author Affiliations
M. Reichardt, Georg-August-Univ. Göttingen (Germany)
J. Frohn, Georg-August-Univ. Göttingen (Germany)
M. Töpperwien, Georg-August-Univ. Göttingen (Germany)
J.-D. Nicolas, Georg-August-Univ. Göttingen (Germany)
A. Markus, Max Planck Institute for Experimental Medicine (Germany)
F. Alves, Max Planck Institute for Experimental Medicine (Germany)
Univ. Medical Ctr. Göttingen (Germany)
T. Salditt, Georg-August-Univ. Göttingen (Germany)


Published in SPIE Proceedings Vol. 10391:
Developments in X-Ray Tomography XI
Bert Müller; Ge Wang, Editor(s)

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