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Proceedings Paper

Fast and low-dose phase contrast CT with non-microfocal laboratory x-ray sources (Conference Presentation)
Author(s): Alessandro Olivo; Paul C. Diemoz; Marco Endrizzi; Charlotte K. Hagen; Fabio A. Vittoria; Alberto Astolfo; Peter R. T. Munro; Peter Modregger; Gibril K. N. Kallon; Dario Basta; Ian Buchanan; Charlotte Maughan Jones; Anna Zamir
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Paper Abstract

The implementation of X-Ray Phase Contrast (XPC) imaging at synchrotrons has demonstrated transformative potential on a wide range of applications, from medicine and biology to materials science. However, translation to conventional laboratory sources has proven more problematic, because of XPC’s stringent requirements in terms of spatial coherence. This has imposed the use of either micro-focal sources, or collimators (e.g. source gratings) where sources with extended focal spots were used. This reduces the available x-ray flux leading to long exposure times, which is often exacerbated by the use of additional optical elements that need to be scanned during image acquisition. Where these elements are placed downstream of the object, they also lead to an increase in the delivered dose. XPC has also been successfully adapted to full 3D, computed tomography (CT) implementations, which has however exacerbated the above concerns in terms of acquisition times and delivered doses. We tackled this problem by developing an incoherent approach to XPC that works with non micro-focal laboratory sources without requiring any additional collimation. The method uses one or two low aspect ratio x-ray masks that are built on low-absorbing graphite substrates for maximum transmission through the mask apertures. The combination of this with a “single-shot” phase retrieval algorithm has enabled the development of a lab-based XPC-CT system that can perform a full scan in a few minutes while delivering low radiation doses. The talk will briefly describe how the method works, then show application examples including direct comparisons with the synchrotron gold standard.

Paper Details

Date Published: 19 September 2017
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Proc. SPIE 10391, Developments in X-Ray Tomography XI, 1039107 (19 September 2017); doi: 10.1117/12.2275487
Show Author Affiliations
Alessandro Olivo, Univ. College London (United Kingdom)
Paul C. Diemoz, Univ. College London (United Kingdom)
Marco Endrizzi, Univ. College London (United Kingdom)
Charlotte K. Hagen, Univ. College London (United Kingdom)
Fabio A. Vittoria, Univ. College London (United Kingdom)
Alberto Astolfo, Univ. College London (United Kingdom)
Peter R. T. Munro, Univ. College London (United Kingdom)
Peter Modregger, Univ. College London (United Kingdom)
Gibril K. N. Kallon, Univ. College London (United Kingdom)
Dario Basta, Univ. College London (United Kingdom)
Ian Buchanan, Univ. College London (United Kingdom)
Charlotte Maughan Jones, Univ. College London (United Kingdom)
Anna Zamir, Univ. College London (United Kingdom)


Published in SPIE Proceedings Vol. 10391:
Developments in X-Ray Tomography XI
Bert Müller; Ge Wang, Editor(s)

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