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Proceedings Paper

New developments in 3D liquid crystal elastomers scaffolds for tissue engineering: from physical template to responsive substrate
Author(s): Marianne E. Prévôt; Leah E. Bergquist; Anshul Sharma; Taizo Mori; Yungxiang Gao; Tanmay Bera; Chenhui Zhu; Michelle T. Leslie; Richard Cukelj; LaShanda T. J. Korley; Ernest J. Freeman; Jennifer A. McDonough; Robert J. Clements; Elda Hegmann
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Paper Abstract

We report here on cell growth and proliferation within a 3D architecture created using smectic liquid crystal elastomers (LCEs) leading to a responsive scaffold for tissue engineering. The investigated LCE scaffolds exhibit biocompatibility, controlled degradability, with mechanical properties and morphologies that can match development of the extracellular matrix. Moreover, the synthetic pathway and scaffold design offer a versatility of processing, allowing modifications of the surface such as adjusting the hydrophilic/hydrophobic balance and the mobility of the LC moieties to enhance the biomaterial performance. First, we succeeded in generating LCEs whose mechanical properties mimic muscle tissue. In films, our LCEs showed cell adhesion, proliferation, and alignment. We also achieved creating 3D LCE structures using either metallic template or microsphere scaffolds. Finally, we recorded a four times higher cell proliferation capability in comparison to conventional porous films and, most importantly, anisotropic cell growth that highlights the tremendous effect of liquid crystal moieties within LCEs on the cell environment.

Paper Details

Date Published: 25 August 2017
PDF: 11 pages
Proc. SPIE 10361, Liquid Crystals XXI, 103610T (25 August 2017); doi: 10.1117/12.2275338
Show Author Affiliations
Marianne E. Prévôt, Kent State Univ. (United States)
Leah E. Bergquist, Kent State Univ. (United States)
Anshul Sharma, Kent State Univ. (United States)
Taizo Mori, Kent State Univ. (United States)
Yungxiang Gao, Kent State Univ. (United States)
Tanmay Bera, Kent State Univ. (United States)
Chenhui Zhu, Lawrence Berkeley National Lab. (United States)
Michelle T. Leslie, Case Western Reserve Univ. (United States)
Richard Cukelj, Kent State Univ. (United States)
LaShanda T. J. Korley, Case Western Reserve Univ. (United States)
Ernest J. Freeman, Kent State Univ. (United States)
Jennifer A. McDonough, Kent State Univ. (United States)
Robert J. Clements, Kent State Univ. (United States)
Elda Hegmann, Kent State Univ. (United States)


Published in SPIE Proceedings Vol. 10361:
Liquid Crystals XXI
Iam Choon Khoo, Editor(s)

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