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Label-free characterization of degenerative changes in articular cartilage by Raman spectroscopy
Author(s): Yusuke Oshima; Mayu Akehi; Hiroshi Kiyomatsu; Hiromasa Miura
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Paper Abstract

Osteoarthritis (OA) is very common joint disease in the aging population. Main symptom of OA is accompanied by degenerative changes of articular cartilage. Raman spectroscopy is a label-free technique which enables to analyze molecular composition in degenerative cartilage. We generated an animal OA model surgically induced by knee joint instability and performed Raman spectroscopic analysis for the articular cartilage. In the result, Raman spectral data of the articular cartilage showed drastic changes in comparison between OA and control side. The relative intensity of phosphate band increases in the degenerative cartilage.

Paper Details

Date Published: 18 April 2017
PDF: 2 pages
Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 1025108 (18 April 2017); doi: 10.1117/12.2275047
Show Author Affiliations
Yusuke Oshima, Ehime Univ. (Japan)
Mayu Akehi, Ehime Univ. (Japan)
Hiroshi Kiyomatsu, Ehime Univ. (Japan)
Hiromasa Miura, Ehime Univ. (Japan)


Published in SPIE Proceedings Vol. 10251:
Biomedical Imaging and Sensing Conference
Toyohiko Yatagai; Yoshihisa Aizu; Osamu Matoba; Yasuhiro Awatsuji, Editor(s)

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