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Proceedings Paper

Ultra-high resolution polarization-sensitive optical coherence tomography for imaging of the retinal nerve fiber layer
Author(s): Barry Cense; Maddipatla Reddikumar; Joel Cervantes
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Paper Abstract

A spectrometer design with a multiple line line-scan camera and beam displacer is presented for ultra-high resolution optical coherence tomography measurements of the human retina at 840 nm. The beam displacer offsets the two orthogonal polarization states on the same line-scan camera, which reduces k-space mapping complexity, as data in both polarization channels can be mapped with the same procedure. Its coherence length is 2.8 μm in tissue (n = 1.38). Birefringence values of 1°/μm and higher were found in a circle with a radius of 2.5° eccentricity centered on the fovea, and in the raphe, pointing at a higher packing density of microtubules and a lower concentration of glia. Birefringence measurements may be more helpful in the modeling of individual structure-function maps than thickness measurements, as they are not affected by glial content.

Paper Details

Date Published: 18 April 2017
PDF: 3 pages
Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 102510S (18 April 2017); doi: 10.1117/12.2275020
Show Author Affiliations
Barry Cense, Utsunomiya Univ. (Japan)
Maddipatla Reddikumar, Utsunomiya Univ. (Japan)
Joel Cervantes, Utsunomiya Univ. (Japan)

Published in SPIE Proceedings Vol. 10251:
Biomedical Imaging and Sensing Conference
Toyohiko Yatagai; Yoshihisa Aizu; Osamu Matoba; Yasuhiro Awatsuji, Editor(s)

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