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Proceedings Paper

Electrolyte gated TFT biosensors based on the Donnan's capacitance of anchored biomolecules
Author(s): Kyriaki Manoli; Gerardo Palazzo; Eleonora Macchia; Amber Tiwari; Cinzia Di Franco; Gaetano Scamarcio; Pietro Favia; Antonia Mallardi; Luisa Torsi
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Paper Abstract

Biodetection using electrolyte gated field effect transistors has been mainly correlated to charge modulated transduction. Therefore, such platforms are designed and studied for limited applications involving relatively small charged species and much care is taken in the operating conditions particularly pH and salt concentration (ionic strength). However, there are several reports suggesting that the device conductance can also be very sensitive towards variations in the capacitance coupling. Understanding the sensing mechanism is important for further exploitation of these promising sensors in broader range of applications. In this paper, we present a thorough and in depth study of a multilayer protein system coupled to an electrolyte gated transistor. It is demonstrated that detection associated to a binding event taking place at a distance of 30 nm far from the organic semiconductor-electrolyte interface is possible and the device conductance is dominated by Donnan’s capacitance of anchored biomolecules.

Paper Details

Date Published: 25 August 2017
PDF: 8 pages
Proc. SPIE 10364, Organic Sensors and Bioelectronics X, 103640J (25 August 2017); doi: 10.1117/12.2274940
Show Author Affiliations
Kyriaki Manoli, Univ. degli Studi di Bari Aldo Moro (Italy)
Gerardo Palazzo, Univ. degli Studi di Bari Aldo Moro (Italy)
CSGI Bari (Italy)
Eleonora Macchia, Univ. degli Studi di Bari Aldo Moro (Italy)
Amber Tiwari, Univ. degli Studi di Bari Aldo Moro (Italy)
Cinzia Di Franco, CNR - Istituto di Fotonica e Nanotecnologie (Italy)
Gaetano Scamarcio, CNR - Istituto di Fotonica e Nanotecnologie (Italy)
Univ. degli Studi di Bari Aldo Moro (Italy)
Pietro Favia, Univ. degli Studi di Bari Aldo Moro (Italy)
Antonia Mallardi, CNR-IPCF, Istituto per i processi chimico fisici (Italy)
Luisa Torsi, Univ. degli Studi di Bari Aldo Moro (Italy)
CSGI Bari (Italy)


Published in SPIE Proceedings Vol. 10364:
Organic Sensors and Bioelectronics X
Ioannis Kymissis; Ruth Shinar; Luisa Torsi, Editor(s)

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