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Proceedings Paper

Micro-Raman analysis of glisterings in intraocular lenses
Author(s): G. Rusciano; A. Martinez; G. Pesce; G. Zito; A. Sasso
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Paper Abstract

The phenomenon of inclusions or microvacuoles in intraocular lenses (IOL), often referred to glistenings due to their appearance when visualized in slit-lamp exams, is main cause of decreased visual in people after IOL implantation. For this reason, there is a huge request by the market of new polymers able to reduce, or even eliminate, the formation of such microvacuoles. In such frame, the use of advanced optical techniques, able to provide a deeper insight on the glistering formation, is strongly required. In particular, Raman spectroscopy (RS) is ideally suited for the analysis of polymers, due to its well-know sensitivity to highly polarizable chemical groups, commonly found in the polymer chains backbones. Moreover, the combination of RS with optical microscopy (Raman micro-spectroscopy) paves the way for real, information-rich chemical mapping of polymeric materials (Raman imaging). In this paper, we analyze the formation of microvacuoles in IOLs following a thermal treatment. In particular, we performed a chemical mapping of a single microvacuole, which allowed us to infer on its effective chemical composition. In order to investigate on the reversibility of glistenings formation, this analysis was repeated as function of time after thermal treatment, in different IOL environments. It turns out that this phenomenon is partially reversible, with an almost complete disappearance of microvacuoles in a dry environment.

Paper Details

Date Published: 26 June 2017
PDF: 5 pages
Proc. SPIE 10333, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials III, 103331A (26 June 2017); doi: 10.1117/12.2271830
Show Author Affiliations
G. Rusciano, Univ. degli Studi di Napoli Federico II (Italy)
National Institute of Optics (Italy)
A. Martinez, Univ. degli Studi di Napoli Federico II (Italy)
G. Pesce, Univ. degli Studi di Napoli Federico II (Italy)
G. Zito, Univ. degli Studi di Napoli Federico II (Italy)
A. Sasso, Univ. degli Studi di Napoli Federico II (Italy)
National Institute of Optics (Italy)


Published in SPIE Proceedings Vol. 10333:
Optical Methods for Inspection, Characterization, and Imaging of Biomaterials III
Pietro Ferraro; Simonetta Grilli; Monika Ritsch-Marte; Christoph K. Hitzenberger, Editor(s)

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