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Proceedings Paper

Optical coherence elastography for cellular-scale stiffness imaging of mouse aorta
Author(s): Philip Wijesinghe; Niloufer J. Johansen; Andrea Curatolo; David D. Sampson; Ruth Ganss; Brendan F. Kennedy
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Paper Abstract

We have developed a high-resolution optical coherence elastography system capable of estimating Young’s modulus in tissue volumes with an isotropic resolution of 15 μm over a 1 mm lateral field of view and a 100 μm axial depth of field. We demonstrate our technique on healthy and hypertensive, freshly excised and intact mouse aortas. Our technique has the capacity to delineate the individual mechanics of elastic lamellae and vascular smooth muscle. Further, we observe global and regional vascular stiffening in hypertensive aortas, and note the presence of local micro-mechanical signatures, characteristic of fibrous and lipid-rich regions.

Paper Details

Date Published: 29 April 2017
PDF: 1 pages
Proc. SPIE 10340, International Conference on Biophotonics V, 1034010 (29 April 2017); doi: 10.1117/12.2269903
Show Author Affiliations
Philip Wijesinghe, The Univ. of Western Australia (Australia)
Niloufer J. Johansen, The Univ. of Western Australia (Australia)
Andrea Curatolo, The Univ. of Western Australia (Australia)
David D. Sampson, The Univ. of Western Australia (Australia)
Ruth Ganss, The Univ. of Western Australia (Australia)
Brendan F. Kennedy, The Univ. of Western Australia (Australia)


Published in SPIE Proceedings Vol. 10340:
International Conference on Biophotonics V
David D. Sampson; Dennis L. Matthews; Jürgen Popp; Halina Rubinsztein-Dunlop; Brian C. Wilson, Editor(s)

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