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Proceedings Paper

Non-label bioimaging utilizing scattering lights
Author(s): Tomonobu M. Watanabe; Taro Ichimura; Hideaki Fujita
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Paper Abstract

Optical microscopy is an indispensable tool for medical and life sciences. Especially, the microscopes utilized with scattering light offer a detailed internal observation of living specimens in real time because of their non-labeling and non-invasive capability. We here focus on two kinds of scattering lights, Raman scattering light and second harmonic generation light. Raman scattering light includes the information of all the molecular vibration modes of the molecules, and can be used to distinguish types and/or state of cell. Second harmonic generation light is derived from electric polarity of proteins in the specimen, and enables to detect their structural change. In this conference, we would like to introduce our challenges to extract biological information from those scattering lights.

Paper Details

Date Published: 18 April 2017
PDF: 2 pages
Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 102510O (18 April 2017); doi: 10.1117/12.2269413
Show Author Affiliations
Tomonobu M. Watanabe, RIKEN Quantitative Biology Ctr. (Japan)
Taro Ichimura, RIKEN Quantitative Biology Ctr. (Japan)
Hideaki Fujita, Osaka Univ. (Japan)


Published in SPIE Proceedings Vol. 10251:
Biomedical Imaging and Sensing Conference
Toyohiko Yatagai; Yoshihisa Aizu; Osamu Matoba; Yasuhiro Awatsuji, Editor(s)

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